UCL  ·  London, UK

Dr David
de Lorenzo

Senior Data Scientist  ·  Genomics Researcher  ·  Educator

Working at the intersection of data science, clinical AI, and personalised genomics. Research Fellow at UCL Great Ormond Street Institute of Child Health. Founder of CESGEN.

30+ Years in science

UCL GOS Institute · Grade 7

2 Countries · Neotree

51 Public repositories

At the intersection of
data, biology, and health

I am a Senior Data Scientist (Grade 7) and Research Fellow at the UCL Great Ormond Street Institute of Child Health, Population, Policy and Practice Department. My career spans more than 30 years at the interface of population genetics, molecular diagnostics, clinical decision support, and education — always with the aim of making data useful for health.

My primary research focus is the Neotree project — a digital health platform for neonatal clinical decision support deployed in Zimbabwe and Malawi. I lead the statistical modelling, machine learning pipelines, interrupted time series analysis, and data governance components.

Alongside research, I am deeply interested in nutrigenomics and personalised medicine — the science of how individual genetic variation shapes responses to diet, environment, and lifestyle. I develop and teach courses on this topic, and build genomic analysis tools through CESGEN and open-source contributions to the ClawBio bioinformatics library.

I have taught mathematics, statistics, and data science at university level for over two decades — in English, Spanish, and German — across institutions in the UK, Spain, and internationally.

UCL Great Ormond Street Institute of Child Health Senior Data Scientist, Grade 7 · Research Fellow
CESGEN SL Founder and Director · Personalised Genomics & Education (Spain)
Member of the Royal Society of Biology MRSB
ONS-accredited researcher Trusted Research Environment access
ORCID: 0000-0003-2042-0961 View full publication list →

Where rigorous methods
meet real-world health

My research sits at the intersection of machine learning, statistics, and global health — asking how AI and rigorous methods can improve clinical decisions in high-stakes, resource-limited settings.

Global Health · Clinical AI

Neotree — Neonatal Clinical Decision Support

A digital health platform deployed in neonatal units in Zimbabwe (Sally Mugabe Central Hospital, Harare) and Malawi (Kamuzu Central Hospital). It captures structured clinical data at point of care and supports clinical decisions, outcome monitoring, and quality improvement.

My role spans interrupted time series analysis evaluating platform impact on neonatal outcomes, machine learning models for early prediction of hypothermia and sepsis, master data pipelines (local and NHS TRE versions), and data governance.

Machine Learning Interrupted Time Series Python · R Sub-Saharan Africa Neonatal Care
Visit Neotree
Genomics · Personalised Medicine

Nutrigenomics and Personalised Medicine

More than two decades of work on the genomic basis of individual variation in health, metabolism, and disease risk — from population genetics and molecular evolution through to SNP-based panels for metabolic nutrition profiling and clinical interpretation pipelines.

Current work focuses on genomic risk scoring, gene-diet interactions, and building scalable open-source analysis pipelines through CESGEN and the ClawBio bioinformatics library.

Nutrigenomics SNP Analysis Population Genetics Bioinformatics CESGEN
Visit CESGEN

Research interests

Clinical decision support in low-resource settings· ML and AI for neonatal outcomes· Interrupted time series methods· Genomics and personalised medicine· Evolutionary biology and molecular evolution· Data governance in global health

Areas of expertise

Built over 30 years across biology, statistics, and computing — applied to research, teaching, and industry.

Machine Learning
Genomics & Bioinformatics
Biostatistics
Python
R · Statistical Computing
Clinical AI
Global Health
Nutrigenomics
Data Governance
Mathematics
Evolutionary Biology
AI & Large Language Models

Online courses, university
teaching, and tutoring

Precise, accessible, grounded in real examples. Two decades of teaching in English, Spanish, and German, across the UK, Spain, and internationally.

CESGEN · Online Course

AI Applied to Genomics

An applied course covering the use of large language models, machine learning pipelines, and AI tools in genomic data analysis. Aimed at researchers, clinicians, and bioinformatics practitioners who want to work effectively with AI in a genomics setting.

View course at CESGEN
CESGEN · Coming Soon

Nutrigenomics 2026

A comprehensive course on the science of personalised nutrition — how individual genetic variation shapes responses to diet, lifestyle, and environment. Covers SNP interpretation, metabolic pathways, gene-diet interactions, and the evidence base behind personalised health recommendations.

Join the mailing list

Open-source projects

I write primarily in Python and R, with a focus on genomics analysis, clinical data pipelines, and machine learning. All public work is on GitHub (51 repositories).

nutrigenomics
Python

Pipeline for interpreting SNP-based genotype data in the context of metabolic nutrition. The analytical core of the CESGEN personalised genomics platform — linking individual genotype profiles to evidence-based nutritional recommendations.

View on GitHub
ClawBio
Python · Contributor

Open-source library of skills for bioinformatics AI agents, built on the OpenClaw runtime. Local-first, reproducible, designed for researchers who want to integrate AI into genomics workflows without losing methodological transparency.

View on GitHub
Neotree
Python · R

Data pipelines and statistical analyses for the Neotree neonatal health project — data ingestion, cleaning, interrupted time series analysis, and machine learning models for clinical prediction. Both local and NHS Trusted Research Environment versions.

View repositories

Connect with me

Science communication, genomics, data science, and everything in between. Find me on the platforms below.

Let's talk

Research, teaching, or consulting

I am always happy to hear from researchers, collaborators, students, and anyone with a genuine interest in data science, genomics, or global health.

London, UK

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